@incollection{,
	
					
					
					2245C784DD15E4800F017392823B64F4
				,
	author={{Erick Hernández, Lisandra Calzadilla, Arturo Toledo, Osvaldo Gozá, Matthias Pietzke, Alexei Vazquez, Giovanny Rodríguez, Anelis Quintana, Kalet Leon, TammyBoggiano}},
	journal={{Global Journal of Researches in Engineering}},
	journal={{GJRE}}2249-45960975-586110.34257/gjre,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}2312131
}

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	title={{Cell culture processes for monoclonal antibody production}}
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	author={{
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}

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	title={{Scaling up your cell cultures to bioreactors}}
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	author={{
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	title={{Editorial-Articles/165203-Scaling-Up-Your-Cell-cultures-to-Bioreactors}}
		
		
			,
	year={July 2014. April 15, 2021}
		
	

}

@incollection{b4,
	
	
		,
	title={{Multivariate data analysis for biotechnology}}
		,
	author={{
			BSwarbrick
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		,
	journal={{bioprocessing. Pharm Manuf}}
		
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	year={2014}
		
	

}

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	title={{Guidance for performing multivariate data analysis of bioprocessing data: pitfalls and recommendations}}
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	author={{
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	title={{Application of multivariate analysis toward biotech processes: case study of a cell-culture unit operation}}
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	author={{
			AOKirdar
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	title={{Application of multivariate data analysis for identification and successful resolution of a root cause for a bioprocessing application}}
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	author={{
			AOKirdar
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			ASRathore
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	journal={{Biotechnol Prog}}
		
	

}

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	title={{}}
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@incollection{b10,
	
	
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	title={{Performance of PLS regression coefficients in selecting variables for each response of a multivariate PLS for omics-type data}}
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	author={{
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	journal={{Adv Appl Bioinform Chem}}
		
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	year={2009}
		
	

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@incollection{b11,
	
	
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	title={{Use of multivariate data analysis (MVDA) for generating process understanding from manufacturing data of biotech processes}}
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	author={{
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@incollection{b12,
	
	
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	title={{Implementing multivariate data analysis to monitor mammalian cell culture processes}}
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	author={{
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			RDKennedy
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			JFaulkner
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	year={2013}
		
	

}

@incollection{b13,
	
	
		,
	title={{Metabolic control in mammalian fed-batch cell cultures for reduced lactic acid accumulation and improved process robustness}}
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	author={{
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		} and {
			CClemens
		} and {
			MMMüller
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	year={2016}
		
	

}

@incollection{b14,
	
	
		,
	title={{Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data}}
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	author={{
			MSokolov
		} and {
			MSoos
		} and {
			BNeunstoecklin
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			AButté
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		10.1002/btpr.2174
		
	
	
		,
	journal={{Biotechnol Prog}}
		
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}

@incollection{b15,
	
	
		,
	title={{Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody}}
		,
	author={{
			MSokolov
		} and {
			JRitscher
		} and {
			MMckinnon
		} and {
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		} and {
			DBrühlmann
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		10.1002/btpr.2374
		
	
	
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	year={2017}
		
	

}

@book{b16,
	
	
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	title={{Sequential multivariate cell culture modeling at multiple scales supports systematic shaping of a monoclonal antibody toward a quality target}}
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	author={{
			MSokolov
		} and {
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			HBroly
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}

@incollection{b17,
	
	
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	title={{}}
		10.1002/biot.201700461
		
	
	
		,
	journal={{Biotechnol J}}
		
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			4
			
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	year={2018}
		
	

}

@incollection{b18,
	
	
		,
	title={{Fermentanomics: relating quality attributes of a monoclonal antibody to cell culture process variables and raw materials using multivariate data analysis}}
		,
	author={{
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		} and {
			SKSingh
		} and {
			MPathak
		} and {
			EKRead
		} and {
			KABrorson
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			CDAgarabi
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	journal={{Biotechnol Prog}}
		
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	year={2015}
		
	

}

@incollection{b19,
	
	
		,
	title={{Multivariate analysis of biological additives for growth media and feeds}}
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	author={{
			RDO'kennedy
		}}
	
	
		,
	journal={{Bioprocess Int}}
		
			14
			3
			
			,
	year={2016}
		
	

}

@book{b20,
	
	
		,
	title={{Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction}}
		,
	author={{
			PZürcher
		} and {
			MSokolov
		} and {
			DBrühlmann
		} and {
			RDucommun
		} and {
			MStettler
		} and {
			JSouquet
		}}
		
		
		
		
		
		
	

}

@incollection{b21,
	
	
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	title={{}}
		10.1002/btpr.3012
		
	
	
		,
	journal={{Biotechnol Prog}}
		
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			,
	year={2020}
		
	

}

@incollection{b22,
	
	
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	title={{Implementing quality by design for biotech products: are regulators on track?}}
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	author={{
			FLuciani
		} and {
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		} and {
			AGaggioli
		} and {
			NAKruse
		} and {
			PVenneugues
		} and {
			CKSchneider
		}}
		
		
		
		
		
		10.1080/19420862.2015.1023058
		
	
	
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	journal={{mAbs}}
		
			7
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			,
	year={2015}
		
	

}

@incollection{b23,
	
	
		,
	title={{Application of Multivariate Process Modeling for Monitor and Control Applications in Continuous Pharmaceutical Manufacturing}}
		,
	author={{
			EMercer
		} and {
			JMack
		} and {
			FTahir
		} and {
			DLovett
		}}
		
		
		
		10.1016/B978-0-12-811065-2.00019-9
		
	
	
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	booktitle={{Multivariate Analysis in the Pharmaceutical Industry}}
				,
	editor={
			APFerreira
			JCMenezes
			MTobyn
		}
		
			,
	publisher={Elsevier Inc}
			2018
			
		
	

}

@incollection{b24,
	
	
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	title={{Industrial experiences with multivariate statistical analysis of batch process data}}
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	author={{
			LHChiang
		} and {
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			RJPell
		} and {
			MBSeasholtz
		}}
		
		
		
		10.1016/j.chemolab.2005.10.006
		
	
	
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	journal={{Chemom Intell Lab Syst}}
		
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	year={2006}
		
	

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@book{b25,
	
	
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	title={{Process Improvement Using Data. Release 3ce778}}
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	author={{
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	year={Copyright 2010-2021 Kevin Dunn; 2021}
		
	

}

@incollection{b26,
	
	
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	title={{Robust classification in high dimensions based on the SIMCA Method}}
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	author={{
			KVBranden
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		10.1016/J.CHEMOLAB.2005.03.002
		
	
	
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	year={2005}
		
	

}

@incollection{b27,
	
	
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	title={{Back to basics: multivariate qualitative analysis}}
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	author={{
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		} and {
			TFearn
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	journal={{SIMCA". Spectrosc Eur}}
		
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	year={2008}
		
	

}

@incollection{b28,
	
	
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	title={{Cross-validation}}
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	author={{
			DBerrar
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		10.1016/B978-0-12-809633-8.20349-X
		
	
	
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	journal={{Encyclopedia of Bioinformatics and Computational Biology}}
		
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	publisher={Elsevier}
		
	

}

@incollection{b29,
	
	
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	title={{Amino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody}}
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	author={{
			LMCarrillo-Cocom
		} and {
			TGenel-Rey
		} and {
			DAraíz-Hernández
		} and {
			FLópez-Pacheco
		} and {
			JLopez-Meza
		} and {
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		}}
		
		
		
		
		
		10.1007/s10616-014-9720-5
		
	
	
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	journal={{Cytotechnology}}
		
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			,
	year={2015}
		
	

}

@incollection{b30,
	
	
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	title={{Statistical methods in media optimization for batch and fed-batch animal cell culture}}
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	author={{
			DMDe Alwis
		} and {
			RLDutton
		} and {
			JScharer
		} and {
			MMoo-Young
		}}
		
		
		
		10.1007/s00449-006-0107-7
		
	
	
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	journal={{Bioprocess Biosyst Eng}}
		
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}

@book{b31,
	
	
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	title={{Uncertainty testing in PLS regression. Spectrosc Eur}}
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	author={{
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	year={2001}
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@incollection{b32,
	
	
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	title={{Multivariate Data Analysis 6th Edition}}
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	author={{
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		}}
		
	
	
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	journal={{Norway: CAMO Software AS}}
		
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	year={2018}
		
	

}

@incollection{b33,
	
	
		,
	title={{Cell culture media for recombinant protein expression in chinese hamster ovary (CHO) cells: history, key components, and optimization strategies}}
		,
	author={{
			FVRitacco
		} and {
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		10.1002/btpr.2706
		
	
	
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	year={2018}
		
	

}

@incollection{b34,
	
	
		,
	title={{Amino acids in the cultivation of mammalian cells}}
		,
	author={{
			ASalazar
		} and {
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		} and {
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		} and {
			J
		}}
		
		
		
		10.1007/s00726-016-2181-8
		
	
	
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	year={2016}
		
	

}

@book{b35,
	
	
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	title={{Cell culture technology for pharmaceutical and cell-based therapies}}
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	author={{
			SSOzturk
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			W-SHu
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	year={2005}
			,
	publisher={CRC Press}
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	address={Boca Raton, FL}
		
	

}

@incollection{b36,
	
	
		,
	title={{Impact of CHO metabolism on cell growth and protein production: an overview of toxic and inhibiting metabolites and nutrients}}
		,
	author={{
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			HFKildegaard
		} and {
			MRAndersen
		}}
		
		
	
	
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	journal={{Biotechnol J}}
		
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	year={2018}
		
	

}

@book{b37,
	
	
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}

@incollection{b38,
	
	
		,
	title={{Specific nutrient supplementation of defined serumfree medium for the improvement of CHO cells growth and t-PA production}}
		,
	author={{
			CAltamirano
		} and {
			AIllanes
		} and {
			RCanessa
		} and {
			SBecerra
		}}
		
		
		
		10.2225/vol9-issue1-fulltext-8
		
	
	
		,
	journal={{Electron J Biotechnol}}
		
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			,
	year={2006}
		
	

}

@incollection{b39,
	
	
		,
	title={{Optimizing amino acid composition of CHO cell culture media for a fusion protein production}}
		,
	author={{
			ZXing
		} and {
			BKenty
		} and {
			IKoyrakh
		} and {
			MBorys
		} and {
			S-HPan
		} and {
			JLLi
		}}
		
		
		
		
		
		10.1016/j.procbio.2011.03.014
		
	
	
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	journal={{Process Biochem}}
		
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			,
	year={2011}
		
	

}

@incollection{b40,
	
	
		,
	title={{Designed amino acid feed in improvement of production and quality targets of a therapeutic monoclonal antibody}}
		,
	author={{
			FTorkashvand
		} and {
			BVaziri
		} and {
			SMaleknia
		} and {
			AHeydari
		} and {
			MVossoughi
		}}
		
		
		
		
		10.1371/journal.pone.0140597
		
	
	
		,
	journal={{PLoS ONE}}
		
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			,
	year={2015}
		
	

}

@incollection{b41,
	
	
		,
	title={{Effect of lipid supplements on the production and glycosylation of recombinant interferon-gamma expressed in CHO cells}}
		,
	author={{
			NJenkins
		} and {
			PCastro
		} and {
			SMenon
		} and {
			AIson
		} and {
			ABull
		}}
		
		
		
		
		10.1007/BF00762395
		
	
	
		,
	journal={{Cytotechnology}}
		
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			,
	year={1994}
		
	

}