New Scientific and Technical Developments in the Areas of Electronic Systems Based on Mass Spectrometry

Table of contents

1.

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Author: e-mail: [email protected] ???????????? ??????????? ????????? ??????????? ????? ????? ????, ????????? ????? ??? 100 ??? ????? [1] .

????????????? ??????,??????? ? ????????????? ????? 20-?? ????,?????? ? ?????? ??????? ????? ? ???????? ?????? CO. ? ? ????????????? ????? 20-?? ????, ??????????? ????? ?????????????? ?????????? ??????????? ??????? (????? ???????? ???? ? ???????????? ????? ?????? ?.?.), ????? ?????????????? ???????????????? ?????????? ????????? ? ??????? ? ??????? ??????? ??? ???????? ?????? ? ???,? ??????? ??????????? ????? ???????????????????????? ?????? ?????????????? ?????? (?STTCO). ???????? ?????????? ???? ????? ???????? ???????????? ?.? ? 1987 ?. ? ??? ??????????? [11] ?? ????????? ??????? ??????? ???.???. ???? ? ? ???????? ?????? [9]- [10] ??????? ?.?., ?????????? ?? ??????????? ? ??? ????????? ???????? ?????????????? ??????? «Advancesin ElectronicsandElectronPhysics». ? ?? ?????? ?STT CO,? 1985 ?.????????????? ?. ?. ????????? ? 1987 ?. ??? ??? ???????????? ??? ???????????? ???????????? ??????? ????????????? TOF MS-FTA? ???????????? ??????-?????? ? ??????? ? ???? ???? ???????????????? ???????????? ???????????????-????????? ??????? ???? ??????? ?????? ? ??????? ??????? ?????? (????????????) ??????????????????? ????? ?????? ???? (??????? ???????). TOF MS-FTA ??? ???????????????? ? 1990 ????.?????????? ???? ????? ???????? ? ?????????? ??????????? [11] ? ? ?????? ?? ??????-????????????????? ?????? [12] .

?( ) sin N h N s ? ? ? ? ?(1)

???:

??????? ?????????? ??????????? ???????? ??????? ??????.

h ??????????? ????? ????? ??????????? 1 S ? ? ?????????? ??????????????? ? ????????????? ????????????? 3D 25â??"R UHR MRMS ???????? ?? ????????????? ??????????? [14] MSFk? ????????????????? (? ??????-??? ??????? ?????????? ? ??????? ?????????? ??????? ??????) ????????? ??????????? ???????? ????????? ????.

?????????? ??????? ??? ????? TOF MSFk????????????? ??????????? ??? ??????????? ???? ? ???????????/????????? ?? ?????? ???????? ??????? ????????????? (????????????? ?????????? ????? ? ??????????? ?? ??????? ?????, ??. ???.9) ?????????? ????? ??????? ?????? (?????????????? ??????? ??? ?????? ????????????? ??? ??????????? 20 0 ?) ?? ?????????, ????? ?????????.

2. VI. ?????????. ????? ?????????? ??????????? ????????? Ms

???????? ???????????? ???????????? ?????, ? 2010 ???? ????? ?????????? ??????????? ??????? ?????????????? ????????????? ??????????? ?????? ???????? ????? $40 ????. ? ?????????????? ?? ??????? ???? ?????? ?? 7% [19] .

?? ????????? ?????????? ????????????????? ???????? ????? MarketsandMarkets, ????? ????????????????? ??????????? ? $4,9 ????. ? 2015 ???? ? ????????? $7,3 ????. ? 2020 ???? ?? ????????????? ?????? ????? ? 8,1% [20] .

? ?????? ?????????? ???????? ? ????????????, ?????????? ??????????????? ??????? ??????? ? ??????? ?????????, ????? ?? ??????????? ??????? ? ???????????? ????? ?????????? ?????.

Figure 1. 2 S
2? ??????????? ????????? ????? ? ?????????? ?????????? ?????????, -s ? ? -??????????? ?????? ?????? ????? ? ?????????? ?????????? ????????? ? ??????? ??? ????????? ? ?????? ???????. -N?????????? ?????????. ??????? 1: ?????? "?????????????? ????????", ??????????? ??? 2D MR TOF-?????????, ? ????????? ??? "Pegasus GC-HRT" ??? ?????????? ????????? (1), ????? ?????????? ????????? ?????? ???????? ?????? ????? N h ? ????????? ????????? ???, ?????????? ????????? ?????????? ????? ?? ????? ??????. ??? ???????????? ?????????? TOFMS, ??????????? ?? ?????? 2DMR?????????. ? ???? ??, ??? ???????????? ?????????? ?????????, ?????? ??????????? ?? ???????????? ????????? ????? ?????? ???????. ? ????????? ????? 2DMRTOFMS ????????? ????????? Leco, ???, ??? ????????? "Pegasus" ?? 2DMRTOF-????????? ? ????? ?????????????????? ????, ????? 45 000. ??????????? ?????? ????? ? ??????? ??????????????? ???? ????? ??????? ????????? ?????? ?????, ???????????? US No. 7,385,187 B2, ?? ??????? ? ????????? ??????????? ??????????? PegasusGC-HRT. ????????????? ?????-?????????? ????? ????? ????, ??????????? ?, ? ????????, ???????????? ?????????????? ?????????. ?? ???. 2????????????????????????????????? ??-????????? ??????????????????? ??????? ?????? ????? ? 3D??2RTOFMS. ???.2: ??????????????????????????? ??????????? ????? ?????????? ?????? ????? ?? ??????? 2 ??????? ??????????? ??????????: ?Z????????? ????????????????????????????? ??????????? ????? ?????????? ?????? ?????; A j??????? ???????????? ?????????, ??? 1, 2,3, 4 j = ; K 1? ? K n? -????????? ???????, ?????????? ??????????? ???????? ?????? ?????; s ? ? ??????????? ?????? ?????? ????? ? ?????????? ?????????? ????????? ? ??????? ??? ????????? ? ???????.
Figure 2. 5
5????????? ?????????? ?? 3-? ?????? ?????????????? ?????? ??????? ? ???????????? ?????????? ??????????, ?? ???? ??????? ?????????????? ????????? ?? ????? ????? ? ????????? ? ???????? ??????? ?????????????? ???????????? ?? ???????? ??????? ?????. ?????????? ?????????????? ????????? ?? ????? ????? ??????????? ?? ?????? ?????????? ????? ???? ? ??????? ??????????? ????? ? ???????????3D 25MRTOFMS. ????????????? 3D 25 UHR MRTOFMS????? ????? ????? ???????? ? ??????? ??????????, ??? ????????? TOFMS.1) 3D 25â??" UHR MRTOFMS???????????????????????????, ???????????? ???????? ????????? ??????? ?????????, ????????????? ?? ???????? ??????????? ????????????????; 2) 3D 25rUHR MRTOFMS????????????????????????????, ??????????? ? ????? ??????????? ?????????????? ????????????? ???????????? ??????? ??????? ?????????; ??????? ?????? 3Dm5rMRTOFMS??????? ?? ??? ??????????? ? ????????????? ????????????? ???????????? ??????????????; 3) 3D UHRS/TOF-F???????????????-????????????, ???????????? ???????? ????????? ??????? ????????? ? ??????? ??????????????? ?????? ????????. ????? ??????????? ????????????????? ?? ??????????? ????????3D 25 UHR MRTOFMS, ?? ???.3-5????????????? ????????3D25rHRT MRTOFMS ? ???????? ?? ?????????????? (???. 3 ? 5) ? ?? ???????????? ????????? (???. 4): ??????-????????? 3D25r HRT MRTOFMS(???. 3); -n -???????/????????-????????? (?????????????) 3D25r HRT MRTOFMS, ????????? ??????????? ???????????, ????????? ??????? ??????????? ?????? ?????? ?????? (???. 4). ????????????? ?????????? 3D 25rUHR MRTOFMS ???????? ????? ?? ?????????????? ?????????-??? 3D25TOFMS, ??????? ?? ???? ??????????? ? ?? ????????? ????? ??????? ?? ??? ???????. a) 3D 25r MRTOFMS ????????????? ?????????? (3D 25r UHR MRTOFMS) ???. ?? ???. 5 ???????? ???????????? ?????????? ???????????. ???????, ?? ?????????? ????? ?????????????? ??? ???????????. ????????????? ?????????? ??????????? ????????? ?????????? ??????? ?????? ??????.
Figure 3. ???. 9
9?? ???. 10, 11 ?-13 ???????? ????????? ??????? ????????? ?????, ?????????????, ?? ??????????? ????????, ??????? ??????.??? ????? ???? ???????????? ? TOF MSFk. ??????????????: ?? ???. 10-????????????????????????????????? ????;?? ???.10 ? 11? ????? ????????????????? ? ?????????????? ???????????????????? ????;?????. 12????????? ???? ?????????? ????????????? ????. ???. 10 ???. 11 ???. 12 ?? ???. 13-15????????????? ???????????? ????????? ??????? ?????????? TOF MSFk, ??? ??????????? ??????? ???????? ?????????? ????? ? ???????????, ??????? ?? ??? ?????????? ??????????? ??????????? ???????? ?????.
Figure 4.
Figure 5.
Figure 6.
Figure 7.
Figure 8.
Figure 9.
Figure 10.
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Aldan Sapargaliyev
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TOFMS -?????????????? ????-???????????;
R -?????????????;
MR -??????????????????;
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????????????.
TOF MS ?????? -???????? ?????? ??????????????????????????????,
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??????????????? ????????????? ??????????
?????????? TOF MS ? EEFE-MS ? ????????
????????????? ?? ?? ?????? ????? ??????, ?
????????? ? ????;
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?.;
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???????????? ? ?. ?.;
Note: TOFMS ? EEFE-MS (EEFE-MS??????????? ??????Ð?"???? ? ????, ?????????? ?? TOF????-
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6 ???????? ????, ????? ???????????????????? ?RMS- 7
Global Journal of Researches in Engineering ( ) Volume XVIII Is sue V Version I F ? ???????????? ?? ?????????? ??????? ????????. ??? ????????, ??? 3D 25â??"R UHR MS ????? ???????????? ???????? ??????????? ????????????????????????( ??????????-????????) ??????????????????,???????????????????? (2 ? ???? ???), ??? ?????? ????????? ???????, ????????, PegasusGC-HRT. ?????? ?????? ???????????? ???????, ??????? ?????????? ???????? ????????????? ??????? ? ??????????????? ?????????? ?????? ??????-???????????? ???????????. (www.OiArna.com; /(https:// drive.google.com/file/d/0B47EiWNeAC2qMzlhSlNuNnd CTU0/ view?usp=sharing). ?????????? ?????????Multipath(??????????? ??????????????????? MS, ????????????????????? ?? ?????????????????-??????????????????????????? ???) ????-???????????-?? ???????????????????????? V. ????????????????? Multipath ??? ????????-????????????? (????????? ?????? ??????? ? ????? ??????) Ms (Ms-Pj) b) ???????????? ???????????-????????????MS(MSFk) ? ?????????????????, ??? k>1 ???????? ??????????? MSFk, ??????????? ? ???????????? ??????????? ??????????? ?????? ????? ?? ?????????????? ?????????????? ? ???????? ??? ???????????? ???????? (?????? ?????????????? ??????? ? ????????? ???? ??????) ??????????????? ????????????? ????? ? ?????? (???????????????-, MS-?????): MSFk???????? ?? 3-? ??? ??????? ??????????, ??? ??? ??????? ? ?????? ??????? ?????????? ?????????????????????????? ??????? ??????? ?????, ??? ??? ???????? ?????? ?????? ???????????? ???????????? ??????? ??????? ??????. ?????????(REIMS,http://www.chemport.ru/datenews.php ?news=3584),iKnife,??????????????????????????????? ???????????????????????????????????,?????????????? ????????????????????????????,???????????????????? ????????????????????????????. ?? ???. 6-8 ???????? ????????? ??????? ????????? ?????, ?? ??????????? ???????, Global sue V Version I ( ) Volume XVIII Is F Journal of Researches in Engineering
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2

Appendix A

  1. , - ??? . 1981. 51 p. .
  2. ????? ?? ??????-????????????????? ??????/?????? ? ???????????? ??????????? ??? ????????????? ??????????????? ????-????????????» (??????????????). ??????? ???.??????????? ?.?., ????????? ???. ???????????, ????-???. http://www.oiarna.com/ Ð?"? 01900024867, ???.?02910040374,38?, 1990.
  3. ????????? ????????? ?????? ??????, ?????????? ? ???????????? ???????????????? ????. -? ??. ?????? ???????? ???? ? ??????????? ?????, ? ?????? , ? ? ??????????? . 1985. p. .
  4. ????? ?????? ???????????????? ? ?????????????? ??????????? ?????????? ??????, ? ???????????? ???????????????? ?????. ???, 1985, ?.55, ?7, ?, ? ? ?????? , ? ? ??????????? , ? ? ???????? . p. .
  5. ?????? ?????? ?????? ?????? ??????????? ?????????? ??????. -???. ?? ??????, ????? ???.-???, ? ? ??????????? , ? ? ?????? . 1980. 2 p. .
  6. ???????????????? ??????????? ? ????? ??????? ?????????? ?????? ? ??????????? ????????. -? ??.: ??????????? ?????? ??????? ??????????-?????????? ??????, ? ? ??????????? . 1986. ???. p. 49.
  7. ????? ?????? ???????????????? ? ???????? ??????????? ??????? ?????????? ?????? ? ???????????? ???????????????? ?????. -?????????, ???, ? ? ??????????? . 2011. ?????-?. p. 327.
  8. ????? ?????? ???????????????? ? ?????-????????? ??????????? ??????? ?????????? ?????? ? ???????????? ???????????????? ?????. -Ð?"?????????? ?? ????????? ?????? ??????? ??????? ??????-?????????????? ????. ? ???????????? . https://drive.google.com/file/d/0B47EiWNeAC2qQzZuVjFlbGRGOXM/view?usp=sharing ?? ?????? ????????, ????-???, 1987, ?.327.
  9. ? Ð?" Ð?"??????? , ? ? ??????????? , ? ? ???????? . ?????? ?.?. ???????????????-????????? ??????????? ?????????? ?????? ? ????? ? ???????????? ??????????,
  10. ????? ????? ??????????? ???????? ?????????????????? ??????? ??? ?????????? ??????, ?????????? ? ???????????????????? ???????? ? ?????? ????, ? Ð?" Ð?"??????? , ? ? ??????????? , ? ? ?????? . 1978. 48 p. .
  11. ????? ??????? ?????????? ?????? ? ??????????? ???????? ? ?????? ????. ???. ?? ??????, ????? ???.-???, ? Ð?" Ð?"??????? , ? ? ??????????? , ? ? ?????? . 1985 ?2. p. .
  12. A ? Sapargaliyev , F Spivak-Lavrovi , Y A Sapargaliyev . MS with 3D-reflective IO Subsystem MP16 326, 61st ASMS Conference on Mass Spectrometry and Allied Topics, (Minneapolis, Minnesota
    ) June 9 -13, 2013.
  13. , A A Sapargaliyev . WO 2015/057042 A2.
  14. , A A Sapargaliyev , A Q Miet , Wo . 2015/012671 A1.
  15. / Theory of electron mirrors and cathode lenses. E M Yakushev , L M Sekunova . Advances in Electronics and Electron Physics, 1986. 68 p. .
  16. Global Analytical Instruments Market: A Competitive Landscape Study, Oct. 11, 2011.
  17. Single mass spectrometry (Quadrupole, TOF, & Ion trap)) & by Application (Pharmaceuticals, Biotechnology) -Analysis & Global Forecast to 2020. http://www.marketsandmarkets.com/Market-Reports/mass-spectrometry-market-437.html(accessedon12.10 Mass spectrometry Market by Platform (Hybrid mass spectrometry (Triple Quadrupole, QTOF, & FTMS), 2016.
  18. Electron beam optics. V M Kelman , S Yavor , Ya . Nauka 1968. p. 487.
  19. Yakushev Evgeniy/ Theory and Computation of electron mirrors. The Central Particle Method. Advances in Imaging and Electron Physics, 2013. 178 p. .
  20. , Y A Sapargaliyev , A A Sapargaliyev , Us . 2014. 8 p. 598. (516 B2; Sapargaliyev A. A., WO 2014/126449 A1 21.08.)
Notes
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Date: 2018-01-15